It is a rare disease that causes blisters on the skin and erosions on the mucosa, including the conjunctiva of the eye, oral, nasal, pharyngeal and genital mucosa. It preferentially affects adults over 60 years of age and is more common in women than in men. It is caused by an autoimmune mechanism, it is like a chronic conjunctivitis that little by little causes fibrosis, symblepharon, entropion and trichiasis. Finally, a fibrous tissue that does not allow light to pass completely covers the conjunctiva and cornea, preventing vision. Evolution is slow and progressive, sometimes leading to blindness after several years.
Treatment: Oral drugs are mainly used, including immunosuppressive agents such as prednisone, methotrexate, azathioprine, and cyclophosphamide.