It is a degenerative disease of the cornea caused by damage to the trigeminal nerve, which causes a loss of corneal sensitivity, the development of spontaneous lesions of the corneal epithelium and the degradation of the ability to heal, which can lead to the development of ulcers, aseptic necrosis and corneal perforation.

Treatment: Stage 1: artificial tears every 2-4 hours and a lubricating ointment overnight to prevent epithelial rupture. Stage 2: corneal / scleral contact lenses and antibiotic eye drops, surgery is reserved for refractory cases, with partial or total tarsorrhaphy being the most common procedure. For refractory neurotrophic corneal ulcers and severe cases with impending perforation, amniotic membrane transplantation and conjunctival sac surgery are performed, respectively. Small perforations are repaired with cyanoacrylate adhesive and therapeutic contact lenses.