It is a syndrome of intolerance to the contact lens, with structural changes in the upper portion of the cornea and the bulbar and tarsal conjunctiva and generally bilateral, rare, frequently associated with thyroid dysfunction. He has papillae in the upper tarsal conjunctiva, hyperemia, and conjunctival staining. It is usually caused by hypersensitivity to certain preservatives used in some maintenance solutions, which can be aggravated by mechanical irritation of the edge of the hydrophilic contact lens.

Treatment: remove the cause and apply a combination of steroids, such as fluorometholone and a broad-spectrum antibiotic for protection. It can lead to states of severe inflammation that will leave sequelae such as epithelial clouding, leukoma, corneal neovascularization, phantom vessels, and corneal distortion.